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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CDKL3 All Species: 22.73
Human Site: S277 Identified Species: 38.46
UniProt: Q8IVW4 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8IVW4 NP_001107047.1 592 67514 S277 D P A D R I S S S D L L H H E
Chimpanzee Pan troglodytes XP_517934 592 67566 S277 D P A D R I S S S D L L H H E
Rhesus Macaque Macaca mulatta XP_001108660 592 67612 S277 D P A D R I S S S D L L H H E
Dog Lupus familis XP_850612 456 51739 I191 I W A L G C M I I E M A T G N
Cat Felis silvestris
Mouse Mus musculus Q8BLF2 595 67720 S277 D P A E R T S S T D L L R H D
Rat Rattus norvegicus Q9JM01 593 67534 S277 D P A E R I S S T D L L H H D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512927 637 71445 S277 D P E D R I S S T A L L H H D
Chicken Gallus gallus P13863 303 34670 E38 A M K K I R L E S E E E G V P
Frog Xenopus laevis P35567 302 34487 L37 V A M K K I R L E N E E E G V
Zebra Danio Brachydanio rerio Q6AXJ9 350 40792 H85 L V F E Y C D H T V L N E L D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P23572 297 34420 M32 L T G Q I V A M K K I R L E S
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_784044 926 104004 C278 D P D Q R P T C T Q F L K H E
Poplar Tree Populus trichocarpa
Maize Zea mays P23111 294 33816 T29 L D K A T N E T I A L K K I R
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P24100 294 34012 T29 R D K V T N E T I A L K K I R
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 98.9 67.7 N.A. 80.5 79 N.A. 57.7 25 24.3 31 N.A. 23.4 N.A. N.A. 30.2
Protein Similarity: 100 99.8 99.6 72.1 N.A. 89.7 87.6 N.A. 68.9 34.9 35.6 43 N.A. 35.1 N.A. N.A. 44
P-Site Identity: 100 100 100 6.6 N.A. 66.6 80 N.A. 73.3 6.6 6.6 6.6 N.A. 0 N.A. N.A. 40
P-Site Similarity: 100 100 100 20 N.A. 86.6 100 N.A. 86.6 13.3 20 26.6 N.A. 20 N.A. N.A. 53.3
Percent
Protein Identity: N.A. 22.8 N.A. 23.1 N.A. N.A.
Protein Similarity: N.A. 33.9 N.A. 33.9 N.A. N.A.
P-Site Identity: N.A. 6.6 N.A. 6.6 N.A. N.A.
P-Site Similarity: N.A. 13.3 N.A. 13.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 8 43 8 0 0 8 0 0 22 0 8 0 0 0 % A
% Cys: 0 0 0 0 0 15 0 8 0 0 0 0 0 0 0 % C
% Asp: 50 15 8 29 0 0 8 0 0 36 0 0 0 0 29 % D
% Glu: 0 0 8 22 0 0 15 8 8 15 15 15 15 8 29 % E
% Phe: 0 0 8 0 0 0 0 0 0 0 8 0 0 0 0 % F
% Gly: 0 0 8 0 8 0 0 0 0 0 0 0 8 15 0 % G
% His: 0 0 0 0 0 0 0 8 0 0 0 0 36 50 0 % H
% Ile: 8 0 0 0 15 43 0 8 22 0 8 0 0 15 0 % I
% Lys: 0 0 22 15 8 0 0 0 8 8 0 15 22 0 0 % K
% Leu: 22 0 0 8 0 0 8 8 0 0 65 50 8 8 0 % L
% Met: 0 8 8 0 0 0 8 8 0 0 8 0 0 0 0 % M
% Asn: 0 0 0 0 0 15 0 0 0 8 0 8 0 0 8 % N
% Pro: 0 50 0 0 0 8 0 0 0 0 0 0 0 0 8 % P
% Gln: 0 0 0 15 0 0 0 0 0 8 0 0 0 0 0 % Q
% Arg: 8 0 0 0 50 8 8 0 0 0 0 8 8 0 15 % R
% Ser: 0 0 0 0 0 0 43 43 29 0 0 0 0 0 8 % S
% Thr: 0 8 0 0 15 8 8 15 36 0 0 0 8 0 0 % T
% Val: 8 8 0 8 0 8 0 0 0 8 0 0 0 8 8 % V
% Trp: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _